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Micro-Series Harry Potter - Rated: One More Time by Rihaan reviews She had all the time in the world, and she used it on everyone else. And what did it cost her in the end? Everything she ever wanted. She went through hell, and back, to lose it all. It was time to make another choice. Her life was going to be exactly what she wanted it to be. Super Max to the rescue; One More Time.

Unequivocally Pricefield, Embarrassingly sweet. Dear Order by SilverWolf reviews "I'm still alive, as you may surmise from this note. Of course, I could be dead and someone is faking the letter to fool you…" Harry is NOT happy about being left at Privet Drive all summer with no one to talk to.

Lord and Ladies by Harry50 reviews With Voldemort resurrected, Dumbledore needed to find a shortcut, enabling the light faction to gain power and stand a chance against the dark.

The one he found proved very enjoyable for Harry Potter and some girls. M for a reason. Better Then by IsraelBlargh reviews Chloe has been dead for five months, and Max can no longer live with the choice she made. She's tried to go back, but her powers are gone. Or are they just dormant? Could she trigger them again with the right motivation? She can only think of one way to find out. Neville has some inconveniences to deal with too.

Junior Inquisitor by sprinter reviews Before the start of fifth year Dumbledore changes the plans. Unfortunately he didn't bother to inform Harry. At his trial, Harry realises that it is down to him to save his own skin. To do so his Slytherin side must come out to play, and once it's out it sticks around turning life at Hogwarts on its head.

This is a parody fic based on Magic: It includes a beach party on Innistrad, a weeaboo Chandra, and some yuri goodness. Rated M for smut. The Gathering - Rated: You're my Density by robst reviews Just Suppose Harry hadn't heeded his godfather's advice, and actually lost his temper at his trial? Time travel fic and title is 'Back to the Future' joke. Ruins of Our Happiness by Knuffol reviews As Chloe and Max escape Arcadia Bay after the storm, they attempt to move forward after the impossible transpired over the course of the most bizarre week in their lives.

Heirs of the Founders by Animekitty2 reviews A more mature, knowledgeable and motivated Harry Potter goes to school. His fated encounter with Hermione Granger comes sooner as they share a compartment aboard the Hogwarts' Express during their first journey to school.

With greater self-confidence, the muggle-born and halfblood will start the long needed reformation of the magical world, hand in hand. M - English - Fantasy - Chapters: An Inconvenient Truth by old-crow reviews After the events in third year, the wizarding world grows darker.

Fudge seems intent on spending more time covering up what's happening than dealing with it. Could a stronger relationship between Harry and the Bones family change history? Somehow, she still expects there to be two.

Emerald Eyes, Silver Tongue by ExaltedChaos reviews Harriet Potter wanted two things in life; to escape from the Dursley's, and to make her mark on the world.

When she is brought back into the world of Magic, it is that second desire that would change everything. Rated for occasional language, mature themes, and general future-proofing. Begins 31 July, , planned to run through all seven books. Harry Potter and the Metamorph by hermyd reviews Harry decided that the only way he can win this war with his sanity intact is to train his own way without interference. But then he discovers an ability that he needs help with and only one person can provide that-Tonks.

They bring the fight to the DEs in their own way so that the war will finally end. Adventures Luna Never Had by alienyouthct reviews A series of miscellaneous one-shots encompassing all sorts of crossover-related adventures that Luna never had. And possibly one or two non-crossover adventures. The jury's still out on that. Category 2 will drift relative to whatever the latest chapter includes. Various characters and pairings included, some may not be canon compliant. A night of Love by Harry50 reviews Sixth year.

Padma asks Harry to help her with a problem, leading to unexpected results. After that small, almost insignificant act, Hogwarts as we knew it fell apart. A classic, revisited seven years later. A Patreon-powered sequel in the works. You get shit done! A grey fanfiction; smut, violence, and jokes galore. Dumbledore and Ron bashing. Harry's relatives were shocked when the Hogwarts letters came. Not because Harry got into Hogwarts. They had expected that. But Dudley, on the other hand That had been a surprise.

Currently in 5th year. Never Give Up by megamatt09 reviews AU. Dolores Umbridge has silenced many critics to the Ministry of Magic by breaking their will, and she's sent to Hogwarts to silence Harry Potter regarding his claims of Voldemort returning. Harry isn't one to fold without a fight. Not for fans of Dolores Umbridge because she will be tormented without mercy. Heart and Soul by Sillimaure reviews The Dementor attack on Harry during the summer after his fourth year leaves him on the verge of having his wand snapped.

Unwilling to leave anything to chance, Sirius Black sets events into motion which will change Harry's life forever. Jasmine Potter revealed her feelings to Hermione, who is willing to give dating a try; but wizarding culture won't tolerate witches as couples. How will they navigate love and a relationship while dealing with Voldemort, bigotry, and meddling old men? Includes growing power, new revelations, ancient conflicts, and hidden prophecies.

Ups and Downs by Harry50 reviews It was only two days since their wedding and they had already had three major quarrels and many more minor ones.

They still slept together. She wondered for how long. The new Mrs Potter by Harry50 reviews Things start changing after the third task, and not necessarily for worse.

Harry's magic makes choices for him and he actually likes the results. A smutty romp that shows that we are more than we appear. To make up for his years of blunders, Harry is sent back in time to correct everything that went wrong and to get some revenge.

Written for humor only. Not having been anyone's friend, let alone best friend, before, Hermione doesn't know what to do.

Luckily, she finds a book by S. Black on how to be the best best friend a guy could ask for. Unwittingly or not she takes everything she reads to heart. Grief Passes by TrippleThreatTrio reviews No matter what choice she picked, she'd have to be able to live with herself. With a harsh breath, she made the choice that would hurt her the least. Make sure you've either played or seen the ending before reading, massive spoilers otherwise. Harry's Loophole by ThinkingSpeck reviews [COMPLETE] Harry has been entered in the Triwizard Tournament, but during the shouting match with Ron he realises that he doesn't actually have to risk his life and look like a fool in front of everyone - he really only needs to show up for each task and make a token effort.

Single-point-of-departure fic, departing early in book 4. Some text borrowed from J. Truly Magical by Little. Xanda reviews Magic was a wonderful thing. Magic was a terrible thing. Both statements were true.

No one knew that better than Hermione. And her only wish was the wonder of Magic would never leave the heart of her best friend. Last year, Jen had to contend with a deadly Tournament, a revived Dark Lord, a meddlesome Headmaster, and worst of all, reconciliation attempts by her parents.

Surely her OWL year can't be anywhere near as complicated. An Anthology of Wizard Wheezes! Probably should not be read by those under Read at your own peril! Harry Potter and the Children of Change by T. Tanglebrooke reviews A 73 year old Harry dies in a tragic accident and finds himself in his 15 month old body again.

I don't own Harry Potter or the universe he finds himself in. Most of the time. Written for the Psychological! The Darkest Diva of his Age by Nightmare Prince reviews On a cold winter's night, inspiration strikes Voldemort that the true way to take over the magical world is to seize control of the music industry.

Thus, he begins his reign as one of the most formidable music moguls in history. In case it isn't yet clear, this is pure crack Harry Potter - Rated: Adorable Violence by Cloud Zen reviews Hermione loves her books.

Hermione loves her Harry. Get between Hermione and either at your own peril. Series of connected one-shots. This wouldn't be such a bad thing if he didn't believe so strongly in the idea that dark wizards just couldn't produce them. Cold blood by DerLaCroix reviews Sometimes, the tide of events really changes a person.

Rated M for themes and language. Bookworm by erbkaiser reviews Everyone knows Hermione is a bookworm. Harry shows up to interrupt her reading with questions on the female body, and perhaps takes things too far Little Guy by Clell reviews What if Lilly was a little more prepared to escape if Voldemort came calling.

She knew that the Floo and Portkeys could be disabled, what if she had found a back door? Just a silly little story of a somewhat different Harry Harry Potter - Rated: Now in an alternative timeline, Harry resolves to right all the wrongs in his previous life, but in order to do this, Harry must pretend to be someone else. This story contains Gender-Bending and Yuri. Hand Delivered Letter by the dork knight reviews Instead of sending his Hogwarts acceptance letter by owl, McGonagall decides to personally deliver to Harry, which sets of a chain of events that changes many aspects of the life of the Boy-Who-Lived.

The Moon Child's Ball by Kaden-san reviews Another take on the Yule ball but with few different mechanics and an entirely new leading lady.

Instead of waiting for the last minute what if Harry asked Luna to the ball? How much would this change the fabric of the HP-verse? First 6 chapter somewhat cannon compliant. It will place 10 'celebrities' in a house together for 2 months.

Friendships and romances will blossom, but rivalries threaten to rip them apart. Who will win 'Listen-In' and the prize of a thousand galleons that comes with it? Liquid Courage by erbkaiser reviews Hermione and Harry are definitely not dating, just living together Strawberry Shampoo by InsomniacHighway reviews Rachel escapes to the locker room to wash off the remnants of a slushy.

Quinn escapes to the locker room to avoid the disapproving stares of the Cheerios. Both girls think they're alone, but when they realize that they aren't Well, let's just say that a bottle of strawberry shampoo can be a powerful thing.

Canon divergence, so AU. He is loyal and devoted to serving the Almighty. The only request is he does not eat the fruit from the one tree. We all know how that story ends. Now Hermione is in danger and Harry's feelings for her begin to change dramatically, jeopardizing everything he once knew. An Epilogue compliant fic. Rated M for sex and language. Hogwarts Rejection Letters by Sweet Kagamine Kiss reviews A folded parchment written in green ink appears, sealed by a wax coat of arms depicting a lion, a badger, a raven, and a snake.

It reads, "Dear Mister Potter Each invitation is responded with ratings in range of Teen to Mature. Granger reviews A Harmony fic featuring a marriage law. One morning at breakfast the lives of a large chunk of Hogwarts students are changed forever. How will they cope? Will there be a happily ever after or will relationships fall apart?

I apologize for a poor summary. Prologue offers more details about the story. Romance Stories by fantasy reviews A collection of short romance stories I wrote, all conveniently right here!

His Choice by sarhea reviews Harry Potter makes a conscious decision to select a wife of his own choice. He was not going to propose to who everyone expected him to.

He was not going to let someone 'older and wiser' push him. He was going to stop and think, use both his mind and his gut feelings. Hermione Granger and the Marriage Law Revolution by Starfox5 reviews Hermione Granger deals with the marriage law the Wizengamot passed after Voldemort's defeat - in the style of the French Revolution.

Old scores are settled but new enemies gather their forces, determined to crush the new British Ministry. Licorice Dueling by Mycroft-mione reviews Flitwick hosts a redo of the dueling club, but there is a surprise guest or two. A Veela bonding fic based on love. T Rated and it will stay that way. Thirteen year old Almost fourteen Gabrielle to start the story. Chess and Snowflakes by iphianeira reviews When someone charms the ceilings to snow, Teddy and Victoire have a chance to spend a day together.

Bipolar Hentai Luck by GoodKing0 reviews It is a truth universally acknowledged, that a young man in possession of a good fortune, must be in want of an Harem. Appleby by Rrit reviews Scorpius has a ratty old blue tee shirt. It was once Rose's, who got it from Tomas. Lucy, who had regifted it to Tomas, was given it by Domonique. Dominique stole it from Louis. Louis received it from Fred who got it from Mild language and medical procedure.

Crossover, of sorts, with Pokemon. Not as stupid as it sounds. Don't look back in Anger by robst reviews Can some angry words change everything? He strikes up a deal with the Devil to go back in time to try and prevent the Wizarding World's downfall. End of GoF onward AU. M - English - Adventure - Chapters: More giant magic robots! And even more crack! If only Lily realized that. Common Sense by DisobedienceWriter reviews My odd ideas file. Little snippets that don't quite merit their own stories.

Some funny; some less so. The two on screen rivals get to know each other a little better after their match. A Prank Gone Wrong or Right? Stuck in a closet with Harry, things take their natural course And Hannah shares her fears about a bit of the future.

As Small As Small Is by MaryRoyale reviews Hermione and Luna are each brilliant in their own way, which is why they make such a great team for experimental spell research. Unfortunately, Hermione bears the brunt of a spell gone wrong, and now she's rather K - English - Chapters: Luna's Tiny Adventure by erbkaiser reviews One day Luna finds herself in a giant bed, or is it she who is tiny?

This follows the prodrome of Fleur and Hermione's initial rendezvous, and their resultant severed ties. Later, Fleur will be unexpectedly summoned to help recover that "someone", now one of England's most famous citizens, and a former Golden Trio member. The same one that broke the Veela, so long ago All because of a broomstick by dark gryffindor harmony reviews Hermione decides to apologize to Harry for getting his Firebolt confiscated in the middle of the night. Secrets are spilled in the confessions that follow.

Pure Harmony Harry Potter - Rated: Too Many Dates by fantasy reviews What if Harry's friends tried to help him out in getting a date to the Yule Ball and he suddenly found himself with too many dates? Hilarity and romance ensues of course. Harry Potter and his Veela Mate by Ares. Granger reviews A Harmony story. Hermione is a Veela and discovers this shortly before their fourth year. What will Hermione's new powers do to alter Harry's fourth year?

Warning- there's Ron-bashing ahead. If you dislike Ron-bashing, don't read. The Turned Page by mrs. But perhaps a new establishment holds tantalizing promise for at least one of the pair - and the proprietor. A Raging Fire by alyssialui She doesn't think he's dangerous when there are more dangerous things out there. They are in the middle of a war and she wants to be with him before it's too late.

Daphne Greengrass doesn't allow herself to relax as often as she should and her health is suffering because of it. Rumour and gossip state that Harry Potter, as an aspiring medical prodigy can help. Massages are supposed to be therapeutic after all On the Way to Greatness by mira mirth reviews As per the Hat's decision, Harry gets Sorted into Slytherin upon his arrival in Hogwarts—and suddenly, the future isn't what it used to be. A fun outlet for some reminded him only of the things he no longer had.

Inspected By No 13 by Clell reviews When he learns that flying anywhere near a Dragon is a recipe for suicide, Harry tries a last minute change of tactics, one designed to use the power of the Bureaucracy forcing him to compete against itself. Little does he know that his solution is its own kind of trap. Theo's Wild Night by firefly81 reviews In which movie night yields some The Unnatural by Fire The Canon reviews When Luna asks Hermione to help her investigate a new magical creature she has discovered Hermione thinks it is nothing more than a waste of time.

But, as the days and weeks go by and she realises Luna knows what she is doing, things change: Harry, Hermione, and Luna get a chance to travel back in time and prevent the hell that England became under Voldemort's rule, and maybe line their pockets while they're at it.

Lunar Harmony; plenty of innuendo, dark humor, some bashing included; manipulative! No Regrets, Yet So Many by HP-Forever-XX reviews "Sirius, This will probably be, without a shadow of a doubt, the strangest letter you've ever received, and if you are indeed reading this, many years from now, then I'm sure you'll remember exactly why I'm writing this.

Of Robots and Women by TheTiller reviews When Chell discovers that she is the last human on Earth, she goes back to the only one she can talk to. What do you do to stop a genocidal dark wizard? If it sinks your entire economy, well That just makes things more interesting. Broomsticks At The Ready! Christmas had never been a happy time for Marlene McKinnon. He doesn't have much to do, so he wanders around, trying to forget. He runs into three determined Gryffindors with nothing but something to eat and drink on their agenda, and it leads to a nice night in the Kitchens.

Hogwarts Besieged by Tamalito reviews Protected behind powerful wards and hidden to the non magical eye. For hundreds of years Hogwarts Castle has been the beacon against evil.

Today all that will change. Harry's Golden Nuggets by Snaggledog reviews Harry takes charge of his fate and the war. He manipulates the wizarding world with revolts, scams and his own vast wealth, but even the best laid plans go awry. His mistake costs him more than he bargains for.

Regardless, he is committed to making his crazy plan work. Begins after GoF - Some Dumbledore bashing. In A Lifetime by Ralinde reviews A collection of unrelated oneshots about the members of the first Order of the Phoenix.

The collection title and chapter titles are based on Clannad's album 'In A Lifetime' though they're not songfics. Lily and Alastor discuss recent events in the Order. The First Wizarding War wasn't the first war Benjy took part in. One Misfired Spell Later by erbkaiser reviews Harry is hit by a misfired undoing spell in third year and starts to remember things causing him to flee together with Hermione and a few others, including a godfather he didn't know he had. For Wizarding Britain and Dumbledore in particular old oaths and secrets are now brought to light.

Luna tries to help. Implied polamory, bisexuality, etc. Harry Crow by robst reviews What will happen when a goblin-raised Harry arrives at Hogwarts. A Harry who has received training, already knows the prophecy and has no scar. With the backing of the goblin nation and Hogwarts herself. Harry Potter, the Geek by Andrius reviews The summer before his fifth year, Harry obtains a computer and an internet connection.

Two months later, he emerges a changed person, for what has been seen cannot be unseen. AU with the whole Harry Potter timeline moved forward to the modern day. References to internet memes, video games, anime, etc. The Coven by Takao reviews Harry has defeated the dark Lord and has no plan of what to do next.

He is with Ginny but doesn't feel like she is right for him. Making a choice he finds the horizon is not so clear or bright until he finishes cleaning his past and finds a new more covert enemy. With the help of a coven of witches can Harry fix the past? Dead Sirius by Rorschach's Blot reviews It's a seriously bad idea to ignore a man's last request. Fourth Year divergence story.

The Harmony Bond by brigrove reviews AU - Harry is rescued from the Dursleys by the Grangers, but they first time they touch, both Harry and Hermione collapse unconscious.

Harry From Another World by sprinter reviews When things go wrong in one world, wizards seek help from another. Unfortunately what you want and what you get can sometimes be entirely different things. Rating for highly probable violence, and likely bad language. Weary Wizard by Yunaine reviews When a few inappropriate questions derail the meeting at the Hog's Head, Harry lets the situation play out.

Eventually, he refuses to commit his free time to teach a bunch of easily distracted fools. Slightly older, and they're still foolishly in love. Slow by Fire The Canon reviews A month after the war, and Ron and Hermione still haven't gotten their acts together, so Ginny decides to take it into her own hands and set them up on an unexpected date. She may just be pleased with the outcome. Endgame by Lara reviews When Percy comes back just before the Battle, no one really knows what to say.

All Fred, George, and Percy can do is hope those good times have not been lost. They want their brother back. Those moments where someone really ought to have taken a step back and asked, "Wait, what? Why I Like You. The Great Dare Game of '96 by APhoenixRising reviews When a freak Dementor attack leaves the students having to sleep in the Great Hall, they expect it to be a boring night filled with the Professors telling them off for being too loud.

So when Fred and George initiate a game of dares, it's safe to say the rest of the school year could become very interesting. But when you're Harry Potter there will never be anything 'normal' about life. He knows he needs to move on, to start over, but what has left behind and what will he do now?

Everything has changed and yet so much remains the same including his romantic life Improbable History by Clell reviews When Harry is six and a half, he meets a pair of strangers on the street.

One is leaving for his own life, and the other is looking to start over. Harry volunteers to help and discovers a world of adventure such as he never dreamed. My claim is Ron, Hermione, Rose and Hugo - family. Sirius searches for his goddaughter and finds her in one of the least expected and worst possible locations and lifestyles. How was he to know just how many problems bringing her home would cause? Harry Harry Potter - Rated: The tide of the war shifts as a new Minister takes power and Harry's training to confront and defeat Voldemort begins.

See Chapter 1 for a better summary. Deathly Musings by loveislouder94 reviews The final thoughts of various Harry Potter characters. The Master of Death meets his fate, too, a long time after the war has been fought and won and the world reforms into a more peaceful kind of chaos.

Even he initially resists, for several reasons. Their names are Ginevra, James, Albus and Lily, and they are not ready to live without him yet. For Allie Harry Potter - Rated: Mirror, Mirror by loveislouder94 reviews Various characters look into the Mirror of Erised. This is the story of an almost-orphan who defied and exceeded all expectations to become a brave and loyal leader. His name is Neville Longbottom, and he is extraordinary. Crackfic set in fourth year.

It's not because they look like his mother's. Super Harry, Good Dumbledore. Rated for violence, swearing,etc. Quoth the Raven, Nevermore by GenkaiFan reviews The Tower of London has a dark and bloody past both in the muggle and wizarding worlds.

Besides being a prison, it also served as a sanctuary in times past, what if it became one yet again? Chudley Canons, She Said by FandaticForeverAndAlways reviews When Dudley decided to attend Harry's wedding, it never crossed his mind that he would find something more than what he bargained for. He had come to seek forgiveness and friendship; in turn, he found a possibility of love.

I don't own HP. Harry is slowly going mad, but through all the darkness, there's one light, guiding him on The Secret Language of Iceland by Fire The Canon reviews On his travels - before marriage, kids, and troublesome nephews - Vernon finds a place he'll never forget. K - English - Adventure - Chapters: Thresholds by Stanrick reviews Most people tend to assume they'll wake up exactly where they fall asleep, and usually they have good reason to do so.

For someone, however, even that simple certainty stops being a given one strange night, when quite surprisingly he does in fact not wake up where he fell asleep. And that is only the beginning of what will be one most unusual week in the life of Harry Potter. Whispers by autumn midnights reviews Dystopian AU. In a world where nobody can leave the city they were born in, Molly and Roxanne make plans to escape.

The Silence of a Spinning Top by sleepy queens reviews Shacklebolt's assassination marked the beginning of it all. A snapshot of insidious oppression. T - English - Suspense - Chapters: Sometimes Opinions Change by Lillielle reviews Disclaimer: His cousin isn't the freak he always knew he was Crash, Bam, Thank You Ma'am by poetzproblem reviews She never thought she'd be grateful for having dated Finn Hudson, but for all the pain, shame, and misery that he'd caused her, he'd also given her one thing for which she's suddenly very grateful—drum lessons.

Target by cherryredxx reviews If I don't follow through, I will become a target. Written for House Cup Competition, round three. Try Again Tomorrow by cherryredxx reviews The light is always better than the dark.

Harry Potter and the Animorphs 1: Instead of five American teenagers, Elfangor gives morphing powers to four young Hogwarts students. It's up to Harry Potter and his friends to stop the Yeerk invasion, even while Voldemort's war threatens to tear them apart. One night during detention, Harry discovers that there are far stranger things in the universe than magic.

He never really understood the reasons why his mother left him when she had a choice to stay back with him. He often wondered if he wasn't enough. But when his mother's letter reached him after few years, Teddy Lupin understood.

Lysander, Lucy, Rose, and making new memories. Not Normal by Radaslab reviews His life was never normal, then it becomes truly abnormal. He must save a world he never cared for, but with others Rated M to be safe. The Love of Your Life by fantasy reviews A 19 year old Harry Potter engaged to Ginny and thinks she is the love of his and only one for him.

What happens when an accident causes him to go into the future and find out what it might be like if he was to choose someone else besides her as he goes through different futures with different girls had he made a different choice? Who will he choose? Moonlight by Montley reviews It's the first full moon after the Final Battle, and Lavender can't help but be scared because of her permanent scars, though there's always a comforting shoulder to lean on.

A book that reveals horrible truths about the world they live in. Prepare for a tougher Harry and a battle focused on the Ministry. T - English - Adventure - Chapters: Well, its pretty similar apart from one major factor. These Lonely Towers by deerlypadfoot reviews And when it comes down to it, who, really, can say that there is any difference between love and war?

Love Before Her Time by maggalina reviews What happens when something goes wrong with the time turner in ? Could Professor McGonagall find in the past what she could never find in the present? What Really Matters by Izzyaro reviews It is said that some Slytherins returned to Hogwarts with Slughorn to fight alongside Harry, but such a decision could not have been an easy one to make.

Especially for those with family on the opposite side. Theodore Nott must finally decide where his loyalties will lie, and one person may make all the difference. It's a broken melody, true, but you've never had a choice in who gets to put it back together, let alone in who gets to play it.

As the fates would have it, it's always been her. Face the World by loveislouder94 reviews "Her world is full of darkness and shadows and immoveable clouds and Seamus is a rainbow that promises something better will come, if only she's prepared to wait it out.

For Nina Harry Potter - Rated: Harry and the Girls by LWJ2 reviews Harry is hiding; news stories have caused him to be pursued relentlessly by females from 11 to Hermione, Luna, Ginny, Padma and Parvati have decided enough is enough. Rated M because of inferences to sex. Through the Storm by slightlysmall reviews "I love you. But they're just words.

They're beautiful, but they're not warm enough to keep out the cold. The thunder followed in an instant. But it's a start, isn't it? See chapter list for songs and pairings.

Various pairings, eras, and ratings - all T or under. Warnings for individual chapters given at the start of each. Together, you make the violin. Infinity by bonniebonbon reviews "Once upon a time, there lived a witch and a monster Wolfstar, a gift for Cassidy. Perfect by Holly The Sparkling Unicorn reviews Your parents died three weeks ago, it's okay to cry, you don't have to be perfect all the time.

Crystal by AlwaysPadfoot reviews Every moment is a reminder and every time he leaves, she falls apart all over again. Truce by autumn midnights reviews Rose Weasley doesn't particularly like Scorpius Malfoy - and he doesn't seem to like her very much either.

But when they're forced to spend a night together, that may very well change. And a fantastic tales of stars and magic and the origin of their names. Four Seasons by Montley reviews Strange to think back of a story of a boy and a girl who never quite knew each other before You-Know-Who's reign, and meeting for the first time on a train during the end of Summer.

Paying The Price by autumn midnights reviews He regrets not being able to save her. He's just not sure if he even could have done so, or if she was so far gone that his attempts wouldn't have mattered.

Daphne Greengrass is dead, and Blaise Zabini doesn't know what to do with himself anymore. Warnings for character death, addiction, and mentions of torture. Peace, Fleeting and Beautiful by Izzyaro reviews In all his life, she was the only light. Only, there's so more than meets the eye to the murder. Emma's Plan by erbkaiser reviews In the summer after Sixth Year Emma Granger, sneaky manipulator and dentist, finds her daughter in a compromising position.

She then tricks her into making the right choice in boys Escapologist Harry by Racke reviews Harry runs away at age four. After bringing him back, Dumbledore's attempts to keep him at Privet Drive gets progressively more ridiculously extreme with each of his escapes. Harry, Crack Harry Potter - Rated: Omnia Vincit Amor by starlight. GodricSalazar, and the wounds that cannot be healed by time:: Tsunami by Empress Empoleon reviews She'll always sweep him off his feet.

Altered Histories by Acaykath reviews They say that history is written by the victor. Harry finds that this is not the case, history is actually written by the manipulative old coot behind the victor, and this Harry is not going to let himself be stepped all over, unless of course Luna tells him to. A Cunning Slytherin by Rorschach's Blot reviews Daphne Greengrass enacts a cunning plan to deal with her housemates' silly objections to her decision to date Harry Potter.

Seeing Death Eaters by erbkaiser reviews Harry is transported to a graveyard following the Third Task of the Tournament, and finds a creative solution to survive the fight with Voldemort and his minions. But that isn't the only magical mirror in the world, as Harry finds out. You think its bureaucrats corrupt, its politicians moronic, its people apathetic sheep? Go make your own! Dormant complications from his meeting with a Basilisk and a Phoenix come to the fore in time to save two very important people in his life.

After a particularly rough welcome to Durzkaban, Harry ends up spending the summer at Katie's house. The two begin to explore the feelings the have for each other as Harry begins to realize his full magical potential. Discretion by LJlashlarue reviews Love may indeed conquer all, but it sometimes breaks things as well.

Fortunately it also sometimes puts them back together, even if in a different way. Written for Femmefest on LJ. Infidelity, Femmesex Harry Potter - Rated: The Meeting by Clell reviews One of the things that many people have wondered about the epilogue was just why Harry and Draco shared a nod The Sole Survivor of the Killing Curse.

Let's take a look and see shall we? Rating will change due to Chapter 4. The odds of temporal displacement were tiny, too infinitesimal to count, and yet… The Harry Potter luck striking again, he supposed. So now there's an older, wiser, more mature Harry well, the older part's true at least stuck in the past.

And he's determined that if he's going to change things, he'll have some fun doing it. Time travel minus angst equals this. K - English - Humor - Chapters: The Reluctant Lord by SmallBurnyThing reviews Five years of intense study and trying to survive has come to its inevitable conclusion and everything's gone to hell in a handcart. A smut fic that got a little too much plot for its own good. The residents of Mockingbird Lane have more secrets than most.

Perhaps their biggest secret is how family comes first and foremost. Once he turns 11, young Harry Munster is offered a place at the Hogwarts School for Witchcraft and Wizardry, but he isn't interested, for four reasons.

Dodgers, Dresses, Teddy bears, and Spot. The ShampooDragon Seduction by LJlashlarue reviews Cho is tired of wishing, and after losing to Gryffindor in Quidditch, she decides to take matters into her own hands. Ginny is frustrated at first, then surprised, then Unfortunately Unbreakable by Luan Mao reviews Unbreakably bound to someone you can't stand? A Curse of Truth by butalearner reviews An avid fanfiction reader falls into the Harry Potter Universe just before the Triwizard Tournament, and has to come to terms with what he's lost, take advantage of what he's gained, and figure out how to deal with the truths he's hiding.

Detailed rune magic, witty banter See my author page for more info. I Wish by AceofRavens reviews Harry gets a few surprises when he goes to Gringott's for a private will reading. He has come to terms with the loss of Sirius, and is in for quite a few shocks Anger him at your own peril. It is not a harem story the way most people think of "harem" in fan fiction.

Hiding in Plain Sight by Clell reviews The summer prior to 6th year Harry deals with Tom in a decisive, if accidental manner.

That summer Harry gets a girl friend in Susan Bones, and sets about some self improvement. It is after this change to himself he discovers something a bit disturbing about the Wizarding World, something that Hermione Granger is determined to use to her advantage. The Accidental Bond by kb0 reviews Harry finds that his "saving people thing" is a power of its own, capable of bonding single witches to him if their life is in mortal danger, with unusual results.

In the Library by vox ad umbram sum reviews Hermione goes to the library to look for a book. She doesn't find it. That may have been a spoiler. There may not be a plot. Wink Wink Harry Potter - Rated: Neither return, and were among the few to escape Britain when Voldemort took over. Years later, their daughter Rose has joined an ICW operation that tries to stop Voldemort's power from spreading beyond Europe.

However things take an unexpected turn when she discovers what became of Harry Potter. Ron Bashing and Deaths. Kill it with Fire! Disillusioned with the effectiveness of the Ministry, Harry turns to the age-old muggle method to solve problems. Distraction by bravenclawesome reviews Ginny takes advantage of her feminine wiles to win at Quidditch. Harry Potter and the Delightful Dilemma by sheltie reviews Reposted.

After Fourth year Hermione decides to take action in helping Harry beat Voldemort. Now Complete with Epilogue. Beware of fluff and cuteness: All are Lily centric, most include James as well. Fresh Start by bisous pour toi reviews Bill's been working a lot in the aftermath of the war, and he hasn't been paying Fleur the attention she deserves She decides to take matters into her own hands.

Making the Carrows lives hell. The Disappearing Act by slightlysmall reviews Being Muggle-born was inconvenient. All these years of just wishing he could disappear - and he could? He could manage that. Mundungus Fletcher was brilliant at disappearing. But is he ready to follow in her footsteps?

K - English - Friendship - Chapters: Paper Airplanes by dark-night-sky reviews Fleur never expected one decision to lead to this. Never expected to be able to pick up the pieces of a shattered life. One mistake seemed like the end of it all, but she never counted on the strangeness of a stranger. To Mark Its Territory by Ladyfun reviews finally gets some alone time she can't help but mark what's hers.

Cue, completely consensual, rough possessive sex maybe with a strap-on Characters: Quinn, Rachel Damn it, I caved to the requests…yes.

Make no mistake, I still loves me some Pezberry Glee - Rated: His little brother came with him, only fifteen years old, and he was carrying a camera. Forever Mine by Forever Siriusly Sirius reviews Today I, Teddy Remus Lupin, consider myself the happiest man on the face of this earth, Teddy thought happily, his hair turning a bright shade of pink as he thought about what was to come. Well, that is, if she says yes. Written for Pink Mockinjay in Hufflepuff and Acciohope15's birthday and a Chrissy gift for rockin around the christmas tree.

So why wouldn't they get together? There was only one solution to this problem It was time for Sirius to act! Hummingbirds by ProfessorSquirrell reviews It's the kind of thing cousins definitely don't think about each other The Cult of Dionysus by Ynyr reviews The blood wards around Privet Drive have a disastrous effect on Harry Potter's magical development, leaving him unable to use a wand. But there are other kinds of magic, and other paths to power.

Luna finds Harry in the forbidden forest, together, they discover something neither of them could ever have imagined. Late At Night by autumn midnights reviews 'She knows, with the three of them, that there's bound to be adventures.

Vicky is not an OC, she's an extremely minor canon character. But sometimes, some dreams just aren't meant to be. Or is he at theirs? Written for samhain-smut on LiveJournal. To Overturn Destiny by The Crownless Queen reviews When Harry stepped through the Veil, he aimed for the Marauder's era because he wanted to defeat Voldemort before he got too powerful.

He hadn't expected his luck to came into play and to send him directly to Riddle. When the boy was just a baby. Christmas in Black and White by slightlysmall reviews "Playing the piano is really difficult; you can't expect to be perfect the first time you try it.

But secondly, and most important, music is a way to express emotion. You have to feel something. And when you press the notes, you sort of let your emotions sink into the piano. K - English - Family - Chapters: Hazel and Grey by silver-nightstorm reviews Her eyes were hazel. He'd never seen a pair of eyes exactly the same color of hers. They had a calm kindness to them that was completely unique and purely her. Took You Long Enough by autumn midnights reviews In fourth year, he fell in love with her appearance.

In fifth year, he fell for her personality. Daphne isn't a typical Slytherin, but she doesn't care - and neither does Theodore.

Can the two get over themselves and get to know each other and try to be friends? Your name is Harry Potter. You have seven days to marry Draco Malfoy. Only one person was ever on your side. She's trying to take over the world. Never having set foot at the Dursley's or Hogwarts, Harry Potter is quite the accomplished thief. Taking to acquiring anything he can get his fingers on, Harry aims to acquire Voldemort's base of power right from underneath him.

As he watches Voldemort's resurrection, he reflects on his life of hardships and pain and comes to a startling revelation. Therole of the MRI in the T staging of rectal cancer is crucial in preoperative assessment of: For successful execution of surgical techniques, good diagnostic imaging of the cancer is necessary in order to have a low level of recurrence.

According to medical studies, the sensitivity of FDG-PET in diagnosing metastatic nodals is low, but for now it is not recommended in routine diagnosis of metastatic colorectal carcinoma. Stages of Rectal Cancer. VEGF inhibitors and angiogenesis inhibitors.

Epidermal growth factor receptor EGFR inhibitor therapy: EGFRs are proteins found on Approach to Rectal Cancer Surgery. Full Text Available Rectal cancer is a distinct subset of colorectal cancer where specialized disease-specific management of the primary tumor is required. There have been significant developments in rectal cancer surgery at all stages of disease in particular the introduction of local excision strategies for preinvasive and early cancers , standardized total mesorectal excision for resectable cancers incorporating preoperative short- or long-course chemoradiation to the multimodality sequencing of treatment.

Laparoscopic surgery is also increasingly being adopted as the standard rectal cancer surgery approach following expertise of colorectal surgeons in minimally invasive surgery gained from laparoscopic colon resections. In locally advanced and metastatic disease, combining chemoradiation with radical surgery may achieve total eradication of disease and disease control in the pelvis. Evidence for resection of metastases to the liver and lung have been extensively reported in the literature. The role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal metastases is showing promise in achieving locoregional control of peritoneal dissemination.

This paper summarizes the recent developments in approaches to rectal cancer surgery at all these time points of the disease natural history. Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer. To establish the feasibility and efficacy of chemotherapy with capecitabine, weekly irinotecan, cetuximab, and pelvic radiotherapy for patients with locally advanced rectal cancer.

Radiotherapy was given to a dose of Resection was scheduled weeks after termination of chemoradiotherapy. On dose level I, no dose-limiting toxicities occurred; however, Grade 3 diarrhea affected 1 of 6 patients on dose level II. Therefore, dose level II was determined as the recommended dose for future studies. All patients underwent surgery. Five patients had a pathologically complete remission and six had microfoci of residual tumor only.

Preoperative chemoradiotherapy with cetuximab, capecitabine, and weekly irinotecan is feasible and well tolerated. The preliminary efficacy is very promising. Larger phase II trials are ongoing.

Phase II study of preoperative radiation plus concurrent daily tegafur-uracil UFT with leucovorin for locally advanced rectal cancer.

Considerable variation in intravenous 5-fluorouracil 5-FU metabolism can occur due to the wide range of dihydropyrimidine dehydrogenase DPD enzyme activity, which can affect both tolerability and efficacy. The oral fluoropyrimidine tegafur-uracil UFT is an effective, well-tolerated and convenient alternative to intravenous 5-FU.

We undertook this study in patients with locally advanced rectal cancer to evaluate the efficacy and tolerability of UFT with leucovorin LV and preoperative radiotherapy and to evaluate the utility and limitations of multicenter staging using pre- and post-chemoradiotherapy ultrasound. We also performed a validated pretherapy assessment of DPD activity and assessed its potential influence on the tolerability of UFT treatment.

The primary endpoints included tumor downstaging and the pathologic complete response pCR rate. Most adverse events were mild to moderate in nature. Pretreatment ultrasound TNM staging was compared with postchemoradiotherapy pathology TN staging and a significant shift towards earlier TNM stages was observed p Surgical outcomes of robot-assisted rectal cancer surgery using the da Vinci Surgical System: We conducted a multi-center pilot Phase II study to examine the safety of robotic rectal cancer surgery performed using the da Vinci Surgical System during the introduction period of robotic rectal surgery at two institutes based on surgical outcomes.

This study was conducted with a prospective, multi-center, single-arm, open-label design to assess the safety and feasibility of robotic surgery for rectal cancer da Vinci Surgical System.

The primary endpoint was the rate of adverse events during and after robotic surgery. The secondary endpoint was the completion rate of robotic surgery. Between April and July , 50 patients were enrolled in this study. Pathologically complete resection was achieved in all patients. There was no intraoperative organ damage or postoperative mortality.

The present study demonstrates the feasibility and safety of robotic rectal cancer surgery, as reflected by low morbidity and low conversion rates, during the introduction period. Published by Oxford University Press. For permissions, please e-mail: CT diagnosis of rectal cancer. Preoperative diagnosis of the depth of invasion and lymph node metastasis of rectal cancer were studied using the findings of computed tomography CT. In conclusion, preoperative CT evaluation of the extension into the rectal wall and lymph node metastasis in rectal cancer was considesed useful.

MRI in local staging of rectal cancer: Preoperative imaging for staging of rectal cancer has become an important aspect of current approach to rectal cancer management, because it helps to select suitable patients for neoadjuvant chemoradiotherapy and determine the appropriate surgical technique. Imaging modalities such as endoscopic ultrasonography, computed tomography, and magnetic resonance imaging MRI play an important role in assessing the depth of tumor penetration, lymph node involvement, mesorectal fascia and anal sphincter invasion, and presence of distant metastatic diseases.

Currently, there is no consensus on a preferred imaging technique for preoperative staging of rectal cancer. However, high-resolution phased -array MRI is recommended as a standard imaging modality for preoperative local staging of rectal cancer , with excellent soft tissue contrast, multiplanar capability, and absence of ionizing radiation. This review will mainly focus on the role of MRI in preoperative local staging of rectal cancer and discuss recent advancements in MRI technique such as diffusion-weighted imaging and dynamic contrast-enhanced MRI.

Preoperative treatment with capecitabine, cetuximab and radiotherapy for primary locally advanced rectal cancer: A phase II clinical trial. Preoperative staging of rectal cancer. Accurate preoperative staging of rectal cancer is crucial for therapeutic decision making, as local tumor extent, nodal status, and patterns of metastatic spread are directly associated with different treatment strategies.

Recently, treatment approaches have been widely standardized according to large studies and consensus guidelines. Introduced by Heald, total mesorectal excision TME is widely accepted as the surgical procedure of choice to remove the rectum together with its enveloping tissues and the mesorectal fascia. Neoadjuvant radiochemotherapy also plays a key role in the treatment of locally advanced stages, while the use of new drugs will lead to a further improvement in oncological outcome. Visualization of the circumferential resection margin is the hallmark of any preoperative imaging and a prerequisite for high-quality TME surgery.

The aim of this article is to present an overview on current cross-sectional imaging with emphasis on magnetic resonance imaging. Future perspectives in rectal cancer imaging are addressed. Chemoradiotherapy response in recurrent rectal cancer.

The efficacy of response to preoperative chemoradiotherapy CRT in recurrent versus primary rectal cancer has not been investigated. We compared radiological downsizing between primary and recurrent rectal cancers following CRT and determined the optimal size reduction threshold for response validated by survival outcomes.

The proportional change in tumor length for primary and recurrent rectal cancers following CRT was compared using the independent sample t-test. A total of patients undergoing CRT were analyzed, 99 with recurrent rectal cancer and with primary rectal cancer. Recurrent rectal cancer appears radioresistant compared with primary tumors for tumor size after CRT. There is strong evidence supporting the importance of the volume-outcome relationship with respect to lung and pancreatic cancers.

This relationship for rectal cancer surgery however remains unclear. We review the currently available literature to assess the evidence base for volume outcome in relation to rectal cancer surgery. Treatment of locally recurrent rectal cancer. The suggested classifications of locally recurrent rectal cancer are based on the presence of symptoms and the degree of tumour fixation to the pelvic wall, or, otherwise, account for factor T in the TMN system.

Although the results of rectal cancer treatment have improved, which may be attributed to total meso rectal excision and application of perioperative radiotherapy and radiochemotherapy, the ratio of cases of locally recurrent rectal cancer still amount from several to over a dozen percent.

Among the available diagnostic methods for detecting locally recurrent rectal cancer after anterior rectal resection, endorectal sonography is of special importance. In the estimation of prognostic factors the lack of vascular invasion in recurrent cancer and the long period between the treatment of primary rectal cancer and the development of recurrence are a sign of good prognosis, while pain prior to recurrence treatment and male sex diminish the chances for cure.

Locally recurrent rectal cancer impairs the patient's quality of life in all measurable aspects, but even after complete recovery we observe severe disturbances of sexual activity in most patients, and a number of patients require hygiene pads or suffer from chronic pain. Local recurrence of rectal cancer is more commonly qualified for excision after surgical treatment only, than after preoperative radiotherapy.

The probability of total recurrent rectal cancer excision increases when the patient is younger, the primary tumours was less advanced and the first operation was sphincter-sparing surgery.

Progress in the surgical treatment of recurrent rectal cancer was brought on by the introduction of the composite musculocutaneous flap to compensate the loss of perineal tissue. The application of intraoperative radiotherapy improves treatment results of recurrent rectal cancer , however at the cost of more frequent, serious postoperative complications and intense pain.

In inoperable cases high dose regional. Drugs Approved for Colon and Rectal Cancer. This page lists cancer drugs approved by the Food and Drug Administration FDA for use in colon cancer and rectal cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

Colon and rectal cancer. This study is about the diagnosis, therapy and monitoring of colon cancer. The techniques used are the endoscopy with biopsy in the pre and post operative colon surgery, abdominal ultrasound, chest X-ray studies of hemogram as well as liver and renal function. A phase I study was conducted to determine the maximal tolerated dose MTD and the dose-limiting toxicity DLT of chemotherapy of oral doxifluridine 5-dFUR and leucovorin with concurrent standard radiotherapy RT as adjuvant treatment in patients with rectal cancer.

The DLTs included grade 3 or grade 4 hematologic and nonhematologie toxicity. Diarrhea is the most common and. Endocavitary radiotherapy of rectal cancer. This analysis was performed to evaluate the results of endocavitary radiotherapy RT administered for early rectal cancer at our institution.

Patient charts were retrospectively reviewed to determine the results of endocavitary RT regarding survival, local control, and complications. Between and , 25 patients were treated with endocavitary RT for early rectal cancer. Twenty had early, low grade tumors and met the criteria for treatment with curative intent.

Five had more advanced, high grade, or multiple recurrent tumors and were treated with palliative intent. The tumors were treated to between 20 and Gy in one to four fractions with 50 KV x-rays given through a specialized proctoscope. Local control and survival were determined using the Kaplan-Meier method. Local control was achieved in 18 of the 20 patients treated with curative intent and 4 of 5 treated with palliative intent. The most significant toxicity was ulceration that occurred in 5 of the 25 patients.

The ulcers were asymptomatic in three cases and associated with bleeding in one case. The fifth patient had pain. One ulcer was biopsied, resulting in perforation that was treated with an abdominal perineal resection APR. There was no tumor found upon pathologic evaluation.

Endocavitary RT can be used to treat patients with early, low-grade rectal cancers and will yield a high level of disease control and a low risk of serious complications. Major advantages of this treatment technique are that it requires neither general anesthesia nor hospitalization. Fournier's Gangrene is a rare complication of rectal cancer.

Its discovery is often delayed. It's incidence is about 0. We report a patient with peritoneal perforation of rectal cancer revealed by scrotal and perineal necrotizing fasciitis. Phase II study of capecitabine Xeloda registered and concomitant boost radiotherapy in patients with locally advanced rectal cancer. Krishnan, Sunil; Janjan, Nora A. The aim of this study was to determine the efficacy of capecitabine Xeloda registered , an oral fluoropyrimidine, as a radiosensitizer in the neoadjuvant treatment of locally advanced rectal cancer LARC.

The primary endpoint was pathologic response rate; secondary endpoints included toxicity profiles and survival parameters. Of the 54 patients median age, Surgery was not performed in 3 patients; 2 of these patients had metastatic disease, and the third patient refused after a complete clinical response. The discussion on the role of adjuvant chemotherapy for rectal cancer patients treated according to current guidelines is still ongoing.

Randomization was based on permuted blocks of six, stratified according to centre, residual tumour, time between last irradiation and surgery, and preoperative treatment. The primary end point was overall survival. Of enrolled patients, were eligible. The trial closed prematurely because of slow patient accrual. After a median follow-up of 5. The HR for disease-free survival was 0. Five-year cumulative incidence for locoregional recurrences was 7.

Five-year cumulative incidence for distant recurrences was However, this trial did not complete. Progress in Rectal Cancer Treatment. The dramatic improvement in local control of rectal cancer observed during the last decades is to be attributed to attention to surgical technique and to the introduction of neoadjuvant therapy regimens. Nevertheless, systemic relapse remains frequent and is currently insufficiently addressed. Intensification of neoadjuvant therapy by incorporating chemotherapy with or without targeted agents before the start of chemo radiation or during the waiting period to surgery may present an opportunity to improve overall survival.

An increasing number of patients can nowadays undergo sphincter preserving surgery. Molecular and genetic biomarkers as well as innovative imaging techniques may in the future allow better selection of patients for this treatment option. The currently available evidence suggests that in complete pathological responders long-term outcome is excellent and adjuvant therapy may be omitted.

The results of ongoing trials will help to establish the ideal tailored approach in resectable rectal cancer. Evidences in multidisciplinary management of rectal cancer. In the last 10 years, a number of important European randomized published studies investigated the optimal management of rectal cancer.

The aim of this article is to present highlights of multidisciplinary rectal cancer management and to compare the conclusions of the international conference on 'Multidisciplinary Rectal Cancer Treatment: Neoadjuvant therapy in rectal cancer.

Rectal cancer causes about deaths a year in our country. The indication for neoadjuvant aims to preserve the sphincter at low tumors and potentially make initially unresectable tumors resectable. Retrospective analysis of 31 records of patients rectal adenocarcinoma treated with neoadjuvant in Oncology Services Hospital and Central Clinical Hospital of the Armed Forces between and , Median age 64 years.

The median dose of R T was 50 Gy Plans Q T used: The most common toxicity was diarrhea and radiodermatitis were the cause of discontinuation in 4 patients. The lack of information recorded in the medical records hindered the Analysis of this work.

Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer. We conducted a single arm phase II study to investigate the feasibility and efficacy of addition of bevacizumab and oxaliplatin to preoperative standard RCT with capecitabine.

Patients received conventionally fractionated radiotherapy The primary study objective was the pCR rate. Development of endoscopic technologies allowed to implement the benefits of minimally invasive surgery in early rectal cancer treatment, decrease morbidity and mortality, improve functional outcome and quality of life. Oncological safety of this method is still a subject for discussion due to lack of lymph node harvest.

Endoscopic operations for early rectal cancer are being actively implemented in daily practice, but lack of experience does not allow to include this method in national clinical prac-tice guidelines. National and international guidelines for rectal cancer. No formal evaluation of the contrasting guidance has been reported.

A systematic search for national and international guidelines on rectal cancer was performed. Eleven guidelines were identified for further analysis. There was no consensus There was consensus concerning a multidisciplinary approach, preoperative chemoradiotherapy CRT and total mesorectal Sexual dysfunction and impaired quality of life is a potential side effect to rectal cancer treatment.

The objective of this study was to develop and validate a simple scoring system intended to evaluate sexual function in women treated for rectal cancer.

This is a population-based cross-sectional study. Female patients diagnosed with rectal cancer between and were identified by using the Danish Colorectal Cancer Group's database.

Participants filled in the validated Sexual Function Vaginal Changes questionnaire. Women declared to be sexually active The primary outcome measured was the quality of life that was negatively affected because Meat and colo- rectal cancer.

In early epidemiological studies of diet and cancer the stress was on the search for causal factors. Population ecological studies tended to show a strong correlation between meat intake, particularly red meat, and the risk of colo- rectal cancer. They also tended to show meat to be strongly inversely correlated with cancers of the stomach and oesophagus and liver. Early case-control studies tended to support the postulated role for red meat in colo- rectal carcinogenesis, although more recent case-control studies, particularly those from Europe, have tended to show no relationship.

The cohort studies in general failed to detect any relationship between meat intake and colo- rectal cancer risk. The available evidence points to the intake of protective factors such as vegetables and whole-grain cereals being the main determinants of colo- rectal cancer risk, with meat intake only coincidentally related.

Radiotherapy for early rectal cancer. Although primary tumor size in rectal cancer has little prognostic value per se, it is obviously important when determining the appropriateness of local therapy. Selecting patients for local therapy based on tumor size alone seems reasonable, since the recurrence and survival rates for the patients are similar to those achieved with radical surgery.

In this chapter, the author describes an additional group of patients who also did well following postoperative radiotherapy after conservative surgical treatment. High-resolution MRI is the best method of assessing the relation of the rectal tumor with the potential circumferential resection margin CRM. Therefore it is currently considered the method of choice for local staging of rectal cancer. The primary surgery of rectal cancer is total mesorectal excision TME , which plane of dissection is formed by the mesorectal fascia surrounding mesorectal fat and rectum.

This fascia will determine the circumferential margin of resection. At the same time, high resolution MRI allows adequate pre-operative identification of important prognostic risk factors, improving the selection and indication of therapy for each patient. This information includes, besides the circumferential margin of resection, tumor and lymph node staging, extramural vascular invasion and the description of lower rectal tumors. All these should be described in detail in the report, being part of the discussion in the multidisciplinary team, the place where the decisions involving the patient with rectal cancer will take place.

The aim of this study is to provide the information necessary to understand the use of high resolution MRI in the identification of prognostic risk factors in rectal cancer.

The technical requirements and standardized report for this study will be describe, as well as the anatomical landmarks of importance for the total mesorectal excision TME , as we have said is the surgery of choice for rectal cancer. Technological advances in radiotherapy of rectal cancer. This review summarizes the available evidence for the use of modern radiotherapy techniques for chemoradiotherapy for rectal cancer , with specific focus on intensity-modulated radiotherapy IMRT and volumetric arc therapy VMAT techniques.

We performed a prospective concurrent CRT Phase II study with irinotecan and capecitabine in patients with locally advanced rectal cancer to investigate the efficacy and safety of this regimen. Patients with locally advanced, nonmetastatic, and mid-to-lower rectal cancer were enrolled. Radiotherapy was delivered in 1. The pathologic responses and survival outcomes were included for the study endpoints.

In total, 48 patients were enrolled; 33 The pathologic complete response rate was The 5-year disease-free and overall survival rates were Grade 3 toxicities included leukopenia 3 [6. There was no Grade 4 toxicity or treatment-related death.

Preoperative CRT with irinotecan and capecitabine with treatment-free weekends showed very mild toxicity profiles and promising results in terms of survival. A prospective phase 2 multicenter trial was performed to investigate the efficacy and safety of preoperative short-course concurrent chemoradiation therapy CRT followed by delayed surgery for patients with locally advanced rectal cancer.

Seventy-three patients with cT rectal cancer were enrolled. Radiation therapy of 25 Gy in 5 fractions was delivered over 5 consecutive days using helical tomotherapy. After 4 to 8 weeks, total mesorectal excision was performed. The primary endpoint was the pathologic downstaging ypStage 0-I rate, and secondary endpoints included tumor regression grade, tumor volume reduction rate, and toxicity.

Seventy-one patients completed the planned preoperative CRT and surgery. Downstaging occurred in 20 Favorable tumor regression grade was observed in 4 5. Preoperative short-course concurrent CRT followed by delayed surgery for patients with locally advanced rectal cancer demonstrated poor pathologic responses compared with conventional long-course CRT, and it yielded considerable toxicities despite the use of an advanced radiation therapy technique.

Phase I and II trial on infusional 5-fluorouracil and gefitinib in combination with preoperative radiotherapy in rectal cancer: Full Text Available Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy CRT in locally advanced rectal cancer LARC.

Adjuvant chemotherapy was administrated in ypN pts. Predictive endpoints of clinical outcomes were tested by univariate and multivariate analysis. Of the 41 initially enrolled pts, 39 were evaluable 27M, 12F.

Long term outcomes and late toxicity were similar to previously reported series. The addition of gefitinib did not improve outcomes in LARC. Further studies may identify if gefitinib is beneficial in selected group of patients.

Rectal cancer , Gefitinib, Log term follow-up, Chemoradiotherapy. To evaluate the efficacy and safety of preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with rectal cancer. Forty patients with locally advanced, nonmetastatic, and mid- to lower rectal cancer were enrolled. Radiotherapy was delivered at a dose of The pathologic responses and survival outcomes were evaluated as study endpoints, and an additional KRAS mutation analysis was performed.

In total, 39 patients completed their planned preoperative chemoradiation and underwent R0 resection. The 3-year disease-free and overall survival rates were KRAS mutations were found in 5 Clinical outcomes were not significantly correlated with KRAS mutation status. Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine was active and well tolerated. KRAS mutation status was not a predictive factor for pathologic response in this study.

Local radiological staging of rectal cancer. Rectal cancer is a common malignancy with a highly variable outcome. Local recurrence is dependent upon tumour stage and surgical technique.

The role of pre-operative imaging is to determine which patients may be safely managed by surgery alone and which need additional therapy in order to facilitate surgery and improve outcome.

This decision depends on the distinction between those with early and advanced disease. While trans- rectal ultrasound has traditionally been used to answer this question, a role for magnetic resonance imaging MRI is increasingly argued.

This review will focus on the treatment options for rectal cancer and the clinical questions that subsequently arise for the radiologist to answer.

Rectal cancer and its treatment impair survivors' productivity. To assess determinants of market and nonmarket employment, job search, volunteering, and homemaking among survivors five years or longer after diagnosis. We mailed questionnaires to survivors who were members of Kaiser Permanente Northern California, Northwest during and Productive activities, functional health status, and bowel management at the time of the survey.

Response rate was Higher comorbidity burdens were associated with lower productivity for men and women rectal cancer survivors. Productive survivors were younger and had lower disease stage and age at diagnosis, higher household income and educational attainment, and fewer comorbidity burdens and workplace adjustments than did nonproductive survivors p rectal cancer survivors were evenly split by sex.

Staying productive is associated with better mental health for rectal cancer survivors. Rectal cancer survivors with multiple chronic conditions, higher disease stage, lower productive activities, and older age need better access to medical care and closer monitoring of the quality of their care, including self-care.

To capture the full extent of the involvement of survivors in all types of productive activities, research should routinely include measures of employment, searching for employment, homemaking, and volunteering. Counting market and nonmarket productive activities is innovative and recognizes the continuum of contributions survivors make to families and society. Health care systems should routinely monitor rectal cancer survivors' medical care access, comorbidities, health-related quality of life, and productive activities.

The aim of the current study is to assess the response rate and toxicity profile in patients with locally advanced rectal cancer using brachytherapy BT boost following external beam radiotherapy EBRT , concomitant with chemotherapy as a component of the neoadjuvant treatment.

This is a prospective phase II study of neoadjuvant chemo-radiation therapy for patients with locally advanced rectal cancer who presented to the department of radiation oncology, King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia.

Seventeen patients had been included in the study. Radiation therapy was given as: All patients received the same concomitant chemotherapy in the form of Capecitabine and Oxaliplatin. The clinical and pathological response rates, together with the toxicity profile were assessed. All patients had low anterior resection LAR. Health-related Quality of Life after complex rectal surgery for primary advanced rectal cancer and locally recurrent rectal cancer.

In study I a review of the literature was undertaken to provide an overview of HRQo Due to the complexity of the treatment and its high The Danish version showed satisfactory psychometric properties for the scales concerning body image, sexual functioning, male sexual problems and defecations problems.

Reduced psychometric properties were found Improved survival after rectal cancer in Denmark. Objective In , an analysis showed an inferior prognosis after rectal cancer in Denmark compared with the other Scandinavian countries.

The Danish Colorectal Cancer Group DCCG was established with the aim of improving the prognosis, and in this study we present a survival analysis of patients The analysis included actuarial overall and relative survival. Results A total of 10 patients were Neoadjuvant capecitabine, radiotherapy, and bevacizumab CRAB in locally advanced rectal cancer: Preoperative capecitabine-based chemoradiation is a standard treatment for locally advanced rectal cancer LARC.

Here, we explored the safety and efficacy of the addition of bevacizumab to capecitabine and concurrent radiotherapy for LARC. Total mesorectal excision was scheduled weeks after completion of chemoradiotherapy.

Tumour regression grades TRG were evaluated on surgical specimens according to Dworak. The primary endpoint was pathological complete response pCR. Median tumour distance from the anal verge was 6 cm range TRG 4 pCR was recorded in 8 patients T-, N- and overall downstaging rates were This study demonstrates the feasibility of preoperative chemoradiotherapy with bevacizumab and capecitabine.

The observed adverse events of neoadjuvant treatment are comparable with those previously reported, but the pCR rate was lower. Locally advanced rectal cancer: Exenterative surgery offers the best long-term outcomes for patients with LARC and locally recurrent rectal cancer so long as a complete R0 resection is achieved.

Accurate preoperative multimodal staging is crucial in assessing the potential operability of advanced rectal tumors, and resectability may be enhanced with neoadjuvant therapies. Unfortunately, surgical options are limited when the tumor involves the lateral pelvic sidewall or high sacrum due to the technical challenges of achieving histological clearance, and must be balanced against the high morbidity associated with resection of the bony pelvis and significant lymphovascular structures.

This group of patients is usually treated palliatively and subsequently survival is poor, which has led surgeons to seek innovative new solutions, as well as revisit previously discarded radical approaches. A small number of centers are pioneering new techniques for resection of beyond-total mesorectal excision tumors, including en bloc resections of the sciatic notch and composite resections of the first two sacral vertebrae.

Despite limited experience, these new techniques offer the potential for radical treatment of previously inoperable tumors. This narrative review sets out the challenges facing the management of LARCs and discusses evolving management options. Staging of rectal cancer by transrectal US.

To evaluate the accuracy of preoperative staging of rectal cancer by transrectal US 7. We correlated the sonographic features of the depth of rectal wall invasion, perirectal fat infiltration and perirectal lymph node metastasis with histopathologic findings. The tumor staging was analyzed according to the TNM classification. The depth of rectal wall invasion was in accordance with histopathologic findings in 15 of 17 cases accuracy: The sensitivity and specificity in predicting perirectal fat infiltration were Perirectal fat infiltration and depth of rectal wall invasion were preoperatively diagnosed with relatively high accuracy, while perirectal lymph node metastasis with low accuracy.

In conclusion, transrectal US is a useful imaging modality for preoperative staging of rectal cancer. Prostatic sarcoma after treatment of rectal cancer. Full Text Available Abstract Background The relationship between radiation exposure for treatment of cancer and occurrence of a second primary cancer at the irradiated site is well known. This phenomenon is however rare in prostate.

Case presentation A year-old farmer was treated for rectal cancer with preoperative 45 Gy of radiotherapy and abdominoperineal resection. Four years later he developed symptoms of bladder outlet obstruction and acute urinary retention. He underwent a transurethral resection of the prostate. Histological examination of the removed prostate tissue and immunohistochemistry revealed it to be a poorly differentiated sarcoma.

Conclusion We believe this to be the first reported case of radiation-induced sarcoma following radiotherapy treatment for rectal cancer. Since radiotherapy plays a pivotal role in the contemporary treatment of rectal adenocarcinoma, it is relevant to be aware of the potential long-term carcinogenic complications of radiotherapy of the pelvis.

Long-term results from a randomized phase II trial of neoadjuvant combined-modality therapy for locally advanced rectal cancer.

Full Text Available Abstract Background This study evaluated the effectiveness and safety of preoperative chemoradiotherapy with capecitabine in patients with locally advanced resectable rectal cancer. This report summarizes the results of the phase II study together with long-term 5-year follow-up. Radiation dose was 45 Gy delivered as 25 fractions of 1.

Surgery was scheduled 6 weeks after the completion of the chemoradiotherapy. Study endpoints included complete pathological remission, proportion of R0 resections and sphincter-sparing procedures, toxicity, survival parameters and long-term 5-year rectal and urogenital morbidity assessment. Results One patient died after receiving 27 Gy because of a pulmonary embolism. Fifty-six patients completed radiochemotherapy and had surgery. Median follow-up time was 62 months. No patients were lost to follow-up.

R0 resection was achieved in 55 patients. A complete pathological response was observed in 5 patients 9. The 5-year overall survival rate, recurrence-free survival, and local control was In 5 patients local relapse has occurred; dissemination was observed in 19 patients and secondary malignancies have occurred in 2 patients. The most frequent side-effect of the preoperative combined therapy was dermatitis. Organ Preservation in Rectal Adenocarcinoma: Joshua; Chow, Oliver S.

Treatment of patients with non-metastatic, locally advanced rectal cancer LARC includes pre-operative chemoradiation, total mesorectal excision TME and post-operative adjuvant chemotherapy. This trimodality treatment provides local tumor control in most patients; but almost one-third ultimately die from distant metastasis.

Most survivors experience significant impairment in quality of life QoL , due primarily to removal of the rectum. A current challenge lies in identifying patients who could safely undergo rectal preservation without sacrificing survival benefit and QoL.

Patients in both arms will be re-staged after completing all neoadjuvant therapy. Those with residual tumor at the primary site will undergo TME. NOM patients will be followed every 3 months for 2 years, and every 6 months thereafter. All will be followed for at least 5 years from the date of surgery or—in patients treated with NOM—the last day of treatment. We will compare the two arms of the study with respect to organ preservation at 3 years, treatment. All will be followed for at least 5 years from the date of surgery or--in patients treated with NOM--the last day of treatment.

We will compare the two arms of the study with respect to organ preservation at 3 years, treatment compliance. Rectal and colon cancer: Not just a different anatomic site. Due to differences in anatomy, primary rectal and colon cancer require different staging procedures, different neo-adjuvant treatment and different surgical approaches.

For example, neoadjuvant radiotherapy or chemoradiotherapy is administered solely for rectal cancer. Neoadjuvant therapy and total. Rectal cancer predominantly affects the elderly. Unfortunately, this age category is under-represented in clinical trials because clinicians are loath to include patients with a high risk of comorbidity. Altogether these results warrant the development of specific optimal therapeutic strategies for the elderly. Detailed preoperative staging using high resolution magnetic resonance imaging MRI enables the selection of patients that require preoperative therapy for tumour regression.

This information can be used to instigate neoadjuvant therapy in those patients with poor prognostic features prior to disturbing the tumour bed and potentially disseminating disease. The design of trials incorporating MR assessment of prognostic factors prior to therapy has been found to be of value in assessing treatment modalities and outcomes that are targeted to these preoperative prognostic subgroups and in providing a quantifiable assessment of the efficacy of particular chemoradiation treatment protocols by comparing pre-treatment MR staging with post therapy histology assessment.

At present, we are focused on achieving clear surgical margins of excision CRM to avoid local recurrence. We recommend that all patients with rectal cancer should undergo pre-operative MRI staging. Of the remainder, those with threatened or involved margins will certainly benefit from pre-operative chemoradiotherapy with the aim of downstaging to permit safe surgical excision.

In the future, our ability to recognise features predicting distant failure, such as extramural vascular invasion EMVI may be used to stratify patients for neo-adjuvant systemic chemotherapy in an effort to prevent distant relapse. The optimal pre-operative treatment regimes for these patients radiotherapy alone, systemic chemotherapy alone or combination chemo-radiotherapy is the subject of current and future trials. Magnetic resonance in the diagnosing of rectal cancer. MR has not yet come into widespread use for the staging of rectal cancer.

However use of MR imaging in diagnosis of rectal cancer gains clinical acceptance. Use contrast media enables exact staging of rectal cancer. MR multiplaner and noninvasive imaging with excellent spatial and contrast resolution has rising popularity in diagnosis of rectal cancer , especially in cases where it is impossible to insert endorectal US-probe because of stenosis. General Information about Rectal Cancer. Treatment Option Overview Rectal Cancer.

Direct costs of radiotherapy for rectal cancer: Radiotherapy provides significant benefits in terms of reducing risk of local recurrence and death from rectal cancer.

Despite this, up-to-date cost estimates for radiotherapy are lacking, potentially inhibiting policy and decision-making. Our objective was to generate an up-to-date estimate of the cost of traditional radiotherapy for rectal cancer and model the impact of a range of potential efficiency improvements. Following interviews and on-site visits to radiotherapy departments in two designated cancer centers, a radiotherapy care pathway for a typical rectal cancer patient was developed. Total direct costs were derived by applying fixed and variable unit costs to resource use within each care phase.

Costs included labor, capital, consumables and overheads. Sensitivity analyses were performed. Traditional radiotherapy for rectal cancer is relatively inexpensive. Moreover, significant savings may be achievable through service organization and provision changes. These results suggest that a strong economic argument can be made for expanding the use of radiotherapy in rectal cancer treatment. UFT tegafur-uracil in rectal cancer. Major achievements in the treatment of localised rectal cancer include the development of total mesorectal excision and the perioperative administration of radiotherapy in combination with continuous infusion CI 5-fluorouracil 5-FU.

This multimodal approach has resulted in extended Pre- and postoperative studies carried out in patients with newly diagnosed or recurrent disease were included. The combination of UFT and radiotherapy was effective and well tolerated Preoperative chemoradiation therapy CRT with capecitabine is a standard treatment strategy in patients with locally advanced rectal cancer LARC.

Concurrent chemotherapy comprised fixed and escalated doses of capecitabine and temozolomide, respectively. The MGMT hypermethylation was evaluated in pretreatment tumor samples. This trial is registered with ClinicalTrials. Dose level 3 was chosen as the RD because DLT was noticeably absent in 10 patients treated up to dose level 3. An additional 12 patients were recruited in this group. Grade III adverse events were noted, and pathologic complete response pCR was observed in 7 patients The pCR rate was Future randomized studies are therefore warranted.

Correlation between tumor regression grade and rectal volume in neoadjuvant concurrent chemoradiotherapy for rectal cancer. To determine whether large rectal volume on planning computed tomography CT results in lower tumor regression grade TRG after neoadjuvant concurrent chemoradiotherapy CCRT in rectal cancer patients. We reviewed medical records of patients treated with surgery following neoadjuvant CCRT for rectal cancer between January and December Rectal volume was contoured on axial images in which gross tumor volume was included.

Average axial rectal area ARA was defined as rectal volume divided by longitudinal tumor length. Average rectal volume and ARA were These results indicate that maintaining minimal rectal volume before each treatment may not be necessary. Local resection of early rectal cancer. The introduction of the National Danish screening programme for colorectal cancer will result in the detection of more early rectal cancers ERC , which may be considered for local excision.

The establishment of a regional or national clinical database is necessary to improve the local treatment of ERC Management of synchronous rectal and prostate cancer.

Although well described, there is limited published data related to management on the coexistence of prostate and rectal cancer. Current management of locally recurrent rectal cancer. A review of the literature was undertaken to provide an overview of the surgical management of locally recurrent rectal cancer LRRC after the introduction of total mesorectal excision TME.

A systematic literature search was undertaken using PubMed, Embase, Web Neoadjuvant Treatment in Rectal Cancer: Neoadjuvant preoperative concomitant chemoradiotherapy CRT has become a standard treatment of locally advanced rectal adenocarcinomas.

It can reduce tumor volume and subsequently lead to an increase in complete resections R0 resections , shows less toxicity, and improves local control rate. The aim of this review is to summarize actual approaches, main problems, and discrepancies in the treatment of locally advanced rectal adenocarcinomas. Louis, Missouri United States. We present here the patient-reported quality of life QOL outcomes from this trial. We examined the role of ostomy on QOL. We also compared QOL with disease outcomes and physician-reported toxicity.

There was no statistically significant change in mean FACT-C scores from before treatment to after treatment. These findings in conjunction. Preoperative chemoradiotherapy with 5-fluorouracil and oxaliplatin for locally advanced rectal cancer: The aim of this study was to report long-term results of patients with locally advanced rectal cancer treated by neoadjuvant chemoradiotherapy with fluorouracil, leucovorin, and oxaliplatin.

From February to November , a total of 58 patients with locally advanced rectal cancer were recruited. Secondary endpoints included the cumulative incidence of local and distant recurrences, disease-free survival, and overall survival. The median follow-up time was months months. The cumulative incidence of local recurrence at 10 years was The cumulative incidence of distant recurrence at 10 years was The overall survival in the intention-to-treat population was Disease-free survival in the intention-to-treat population was Univariate analysis revealed that pathologic complete response was associated with local recurrence, distant recurrence, disease-free survival, and overall survival p rectal cancer after preoperative chemoradiotherapy and total mesorectal excision.

Pathologic complete response is an independent prognostic factor for locally advanced rectal cancer after preoperative chemoradiotherapy. Clinical target volume for rectal cancer. The total meso- rectal excision allows the marked increase of the local control rate in rectal cancer. Therefore, the meso- rectal space is the usual field for the spread of rectal cancer cells. It could therefore be considered as the clinical target volume in the preoperative plan by the radiation oncologist.

We propose to identify the mesorectum on anatomical structures of a treatment-position CT scan. Full Text Available Purpose. We report the long-term results in patients treated within two sequential clinical trials. KRAS exon 2 mutational status had been analyzed in patients receiving cetuximab. Median follow-up time was The median OS was Follow-up after rectal cancer. The main treatment for non-metastatic rectal cancer RC is surgical resection.

Late adverse effects that are highly prevalent and negatively impact patients' symptom burden and quality of life are: As a consequence, the randomized controlled trial Follow-up after Rectal Cancer FURCA has been launched, testing the effect of a new patient-led, follow-up program. The aim of this paper is to describe the methodology used in the FURCA study and to report results from the development of the patient-led, follow Other outcome and demographic data are collected as patient A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer.

The aim of this study was to evaluate the efficacy and tolerance of preoperative chemoradiotherapy CRT with irinotecan CPT and 5-fluorouracil 5-FU in patients with resectable rectal cancer. A total of 74 patients were enrolled: Of the 73 resected specimens, This preoperative CRT schedule has been shown to be effective and feasible in a large population of patients with resectable rectal cancer.

We have previously shown that the addition of cetuximab to chemoradiation therapy failed to improve complete response rates pCR in rectal cancer. The median follow-up was 63 months range, months.

Sixty patients were enrolled; 3 patients were excluded due to protocol violation, and 4 died before surgery. The prognostic value of KRAS mutation status was also assessed. In the 45 patients who were treated with curative intent M0 , the OS rates at 1, 3, and 5 years were Chronic toxicity was rare.

KRAS mutations, as detected in Taken together, chemoradiation therapy combined with cetuximab is safe, feasible, and offers excellent survival rates. KRAS mutation status was not a predictive factor. Importantly, lack of improvement in pCR rate did not. It contains details of the full membership of the clinical teams providing care for colon and rectal cancer in each of Health and Social Services Board Area.

Evidence and research in rectal cancer. The main evidences of epidemiology, diagnostic imaging, pathology, surgery, radiotherapy, chemotherapy and follow-up are reviewed to optimize the routine treatment of rectal cancer according to a multidisciplinary approach. This paper reports on the knowledge shared between different specialists involved in the design and management of the multidisciplinary ESTRO Teaching Course on Rectal Cancer.

The scenario of ongoing research is also addressed. In this time of changing treatments, it clearly appears that a common standard for large heterogeneous patient groups have to be substituted by more individualised therapies based on clinical-pathological features and very soon on molecular and genetic markers.

Only trained multidisciplinary teams can face this new challenge and tailor the treatments according to the best scientific evidence for each patient. Despite advances in rectal cancer treatment over the last decade, local control and risk of late side effects due to external beam radiation therapy EBRT remain as concerns.

The present study aimed to investigate the efficacy and the safety of low-dose-rate endorectal brachytherapy LDRBT as a boost to neoadjuvant chemoradiation for use in treating locally advanced distal rectal adenocarcinomas. For comparative analysis, matched patients as the historical control arm with rectal cancer were also selected.

The study results revealed a significant differences between the study arm and the control arm in terms in the pathologic tumor size 2. To evaluate the efficacy and safety of upfront mFOLFOX6 followed by short-course radiotherapy SCRT and surgery in patients with locally advanced rectal cancer and liver-only metastases.

This single-arm phase II study involved 32 patients.